Multivariate tests of association based on univariate tests
نویسندگان
چکیده
For testing two vector random variables for independence, we propose testing whether the distance of one vector from an arbitrary center point is independent from the distance of the other vector from another arbitrary center point by a univariate test. We prove that under minimal assumptions, it is enough to have a consistent univariate independence test on the distances, to guarantee that the power to detect dependence between the random vectors increases to one with sample size. If the univariate test is distribution-free, the multivariate test will also be distribution-free. If we consider multiple center points and aggregate the center-specific univariate tests, the power may be further improved, and the resulting multivariate test may have a distribution-free critical value for specific aggregation methods (if the univariate test is distribution free). We show that certain multivariate tests recently proposed in the literature can be viewed as instances of this general approach. Moreover, we show in experiments that novel tests constructed using our approach can have better power and computational time than competing approaches.
منابع مشابه
A family-based robust multivariate association test using maximum statistic.
For characterizing the genetic mechanisms of complex diseases familial data with multiple correlated quantitative traits are usually collected in genetic studies. To analyze such data, various multivariate tests have been proposed to investigate the association between the underlying disease genes and the multiple traits. Although these multivariate association tests may have better power perfo...
متن کاملFinite-Sample Diagnostics for Multivariate Regressions with Applications to Linear Asset Pricing Models
In this paper, we propose several finite-sample specification tests for multivariate linear regressions (MLR) with applications to asset pricing models. We focus on departures from the assumption of i.i.d. errors assumption, at univariate and multivariate levels, with Gaussian and non-Gaussian (including Student t) errors. The univariate tests studied extend existing exact procedures by allowin...
متن کاملA Unified Framework for Association Analysis with Multiple Related Phenotypes
We consider the problem of assessing associations between multiple related outcome variables, and a single explanatory variable of interest. This problem arises in many settings, including genetic association studies, where the explanatory variable is genotype at a genetic variant. We outline a framework for conducting this type of analysis, based on Bayesian model comparison and model averagin...
متن کاملOn the Canonical-Based Goodness-of-fit Tests for Multivariate Skew-Normality
It is well-known that the skew-normal distribution can provide an alternative model to the normal distribution for analyzing asymmetric data. The aim of this paper is to propose two goodness-of-fit tests for assessing whether a sample comes from a multivariate skew-normal (MSN) distribution. We address the problem of multivariate skew-normality goodness-of-fit based on the empirical Laplace tra...
متن کاملTest selection with application to detecting disease association with multiple SNPs.
We consider the motivating problem of testing for association between a phenotype and multiple single nucleotide polymorphisms (SNPs) within a candidate gene or region. Various statistical approaches have been proposed, including those based on either (combining univariate) single-locus analyses or (multivariate) multilocus analyses. However, it is known in theory that there is no single unifor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016